Funding History

Active Funding:

  1. Title: Effect of Deployment Angle on the Lap Shear Strength of Absorbable Fixation Devices in Porcine Abdominal Wall Tissue
    Role: Principal Investigator                      
    Sponsor: Covidien
    Goals: The major goals of this project are to evaluate the fixation strength achieved when various types of absorbable fixation devices are utilized to attach synthetic mesh to the porcine abdominal wall at implantation angles of 30, 45, 60, and 90 degrees.

Past Funding:

  1. Title: Cyclic Loading of Hernia Mesh Prototypes
    Role: Principal Investigator
    Sponsor: Covidien
    Goals: The major goals of this project are to evaluate the mechanical and histological properties of 5 prototypes of 2-dimensional, monofilament PET mesh via benchtop and in vivo techniques in order to determine the effect of porosity and mesh density on tissue ingrowth, foreign body response, and mechanical properties
  2. Title:  Anti-Adhesion Study on Kensey Nash Corporation Surgical Meshes
    Role:  Principal Investigator
    Sponsor:  Kensey Nash Corporation
    Goals:  The major goals of this project are to evaluate the anti-adhesion properties of surgical mesh materials using a rabbit model with abrasion of the cecum to stimulate adhesion formation.
  3. Title: Histological Analysis of Explanted Hernia Mesh Materials
    Role: Principal Investigator
    Sponsor: Atrium Medical Corporation
    Goals: The major goals of this project are to evaluate the histological characteristics of synthetic mesh materials explanted from human subjects.
  4. Title: Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol (PEG) Sealant in a Porcine Model
    Role: Principal Investigator
    Sponsor: Society of American Gastrointestinal and Endoscopic Surgeons
    Goals: The major goals of this project are to evaluate the fixation strength of porcine small intestine submucosa biological mesh at the hiatus using two types of biological sealants.
  5. Title: Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol (PEG) Sealant in a Porcine Model
    Role: Principal Investigator
    Sponsor:  Baxter Healthcare
    Goals: The major goals of this project are to evaluate the fixation strength of porcine small intestine submucosa biological mesh at the hiatus using two types of biological sealants.
  6. Title: Fixation of Biologic Mesh at the Hiatus with Fibrin or Polyethylene Glycol (PEG) Sealant in a Porcine Model
    Role: Principal Investigator
    Sponsor: Cook Biotech
    Goals: The major goals of this project are to evaluate the fixation strength of porcine small intestine submucosa biological mesh at the hiatus using two types of biological sealants.
  7. Title: Enzymatic Degradation of Biological Tissue-Based Scaffold Materials and the Effect on Tensile Strength Over Time
    Role: Principal Investigator
    Sponsor: Musculoskeletal Transplant Foundation Dermal Tissue Research Grant
    Goals: The major goals of this project are to elucidate how variables such as tissue type and processing conditions affect the scaffold’s ability to resist enzymatic degradation and retain its original tensile strength over a variety of exposure times.
  8. Title: A Prospective Multicenter Trial to Evaluate Adhesion Characteristics and Adhesiolysis-related Complications of Barrier-coated and Non-barrier-coated Intraperitoneal Mesh During Abdominal Re-exploration After Prior Ventral Hernia Repair
    Role: Co-Investigator (PI: Cavallo)
    Sponsor: NIH KM1
    Goals: The major goals of this project are to compare the benefits, harms, and comparative effectiveness of intraperitoneal barrier-coated and non-barrier coated VHR mesh in reducing adhesions, adhesion related complications, and adhesiolysis sequelae in actual patient subpopulations and clinical circumstances.
  9. Title: Nanofiber Materials for Hernia Repair
    Role:  Co-Investigator (PI: Moran)
    Sponsor:  Washington University Fund for Translation Research                     
    Goals: The major goal of this project was to develop novel, nanofabricated meshes and materials for use in the surgical repair of hernia defects and other soft-tissue repair procedures.
  10. Title: A Prospective Multicenter Trial to Evaluate Adhesion Characteristics and Adhesiolysis-related Complications of Barrier-coated and Non-barrier-coated Intraperitoneal Mesh During Abdominal Re-exploration After Prior Ventral Hernia Repair
    Role: Co-Investigator (PI: Matthews)
    Sponsor: Atrium Medical Corporation
    Goals: The major goals of this project are to compare the benefits, harms, and comparative effectiveness of intraperitoneal barrier-coated and non-barrier coated VHR mesh in reducing adhesions, adhesion-related complications, and adhesiolysis sequelae in actual patient subpopulations and clinical circumstances.
  11. Title: Effects of Enzymatic Degradation and Repetitive Loading on the Tensile Strength of Crosslinked and Non-Crosslinked Porcine Dermis
    Role: Principal Investigator
    Sponsor: Covidien Investigator Sponsored Research Grant
    Goals: The major goals of this project are to determine the effects of enzymatic degradation and repetitive loading on the tensile strength of three porcine dermis scaffold materials to improve surgeons’ understanding of which materials are at risk for rapid loss of strength in contaminated or high stress environments.
  12. Title: Physicomechanical Evaluation of a Collagen-Based Hernia Repair Material
    Role: Principal Investigator
    Sponsor: OBI Biologics, Inc.
    Goals: The major goals of this project are to evaluate the physicomechanical properties of a collagen-based hernia repair material via laser micrometry, suture retention, tear resistance, and ball burst testing.
  13. Title: Effect of Implantation Angle on the Fixation Strength of Absorbable Fixation Devices in Porcine Abdominal Wall Tissue
    Role: Principal Investigator
    Sponsor: Ethicon, Inc.
    Goals:  The major goals of this project are to evaluate the fixation strength achieved when absorbable fixation devices are utilized to attach permanent mesh materials to the porcine abdominal wall at a variety of implantation angles.
  14. Title:  Characterization of Hernia Repair Materials
    Role: Principal Investigator
    Sponsor: Atrium Medical Corporation
    Goals: The major goals of this project are to evaluate the physiomechanical properties of a novel hernia repair material via physical, thermal, and enzymatic characterization techniques.
  15. Title: Protocol Development for Evaluation of Fortiva in a Porcine Model of Ventral Hernia Repair
    Role: Principal Investigator
    Sponsor: RTI Surgical
    Goals: The major goals of this project are to develop a protocol for a porcine study to evaluate Fortiva in a functional hernia repair model.
  16. Title: Impact of ADMs on Biofilms Around Breast Implants
    Role: Co-Investigator (PI: Myckatyn)
    Sponsor: ASERF
    Goals: The major goals of this project are to evaluate biofilm formation approximately 3 to 24 months after placement of a textured tissue expander in the presence of an acellular dermal matrix